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  1. Home
  3. Hippocampal Nop Receptor Activation Impairs Object Recognition Memory Acquisition.
  1. Home
  3. Hippocampal Nop Receptor Activation Impairs Object Recognition Memory Acquisition.

Related Experiment Video

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Lucas Ribeiro1, Rodrigo Orvate1, Johseph P de Souza1

  • 1Memory Research Laboratory - Brain Institute, UFRN, Natal, Rio Grande do Norte, Brazil.

Hippocampus
|May 23, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Nociceptin/orphanin FQ (N/OFQ) infusion into the hippocampus impairs object recognition memory acquisition. This N/OFQ-NOP system negatively impacts memory encoding, but not consolidation or recall.

Keywords:
N/OFQUFP‐101hippocampusnociceptinobject recognition memory

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Published on: August 20, 2020

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Molecular Psychiatry

Background:

  • Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the NOP receptor.
  • N/OFQ plays a role in learning and memory, but its specific function in the hippocampus is not fully understood.
  • Object recognition memory (ORM) is a hippocampus-dependent memory process.

Purpose of the Study:

  • To investigate the role of hippocampal NOP receptors in different stages of object recognition memory (ORM).
  • To determine if N/OFQ administration affects memory acquisition, consolidation, or recall.
  • To identify the N/OFQ-NOP system's influence on hippocampal memory encoding mechanisms.

Main Methods:

  • Adult male Wistar rats were trained in the novel object recognition task.
  • Bilateral intra-dorsal CA1 infusions of N/OFQ were administered before training, after training, or before a retention test.
  • The NOP receptor antagonist UFP-101 was used to block N/OFQ effects.
  • Locomotor activity, exploratory behavior, and performance in the step-down inhibitory avoidance task were assessed.

    • Main Results:

    • Pre-training N/OFQ infusion significantly impaired ORM retention without affecting locomotor or exploratory behavior.
    • Post-training or pre-test N/OFQ infusions had no effect on memory retention.
    • The NOP receptor antagonist UFP-101 completely blocked the amnesic effect of N/OFQ.
    • N/OFQ did not affect performance in the step-down inhibitory avoidance task, ruling out sensory or motivational confounds.

    Conclusions:

    • Hippocampal NOP receptor activation selectively disrupts ORM acquisition.
    • The N/OFQ-NOP system does not affect memory consolidation or recall.
    • The N/OFQ-NOP system acts as a negative modulator of hippocampal encoding processes crucial for recognition memory.