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Related Concept Videos

Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.

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Related Experiment Video

Updated: May 24, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy.

Amanda G Sandoval Karamian1, Tianjia Zhu2,3, Hao Huang2,4

  • 1Division of Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Annals of Clinical and Translational Neurology
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

Neonatal genetic epilepsy is linked to abnormal white matter microstructure, specifically higher fractional anisotropy (FA) and lower mean diffusivity (MD) in key brain pathways. These findings highlight early white matter impacts in infant epilepsy.

Keywords:
genetic epilepsyneonatal seizureswhite matter

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Pediatric Neurology

Background:

  • Epilepsy in neonates is associated with white matter abnormalities.
  • Rapid myelination during infancy may amplify seizure-induced white matter changes, affecting brain networks, epileptogenesis, and cognition.
  • Genetic epilepsies without structural brain abnormalities in neonates offer a model to study seizure-related white matter alterations.

Purpose of the Study:

  • To investigate white matter structure in neonates with genetic epilepsy.
  • To determine if seizures in neonates impact white matter integrity during a critical developmental period.

Main Methods:

  • Retrospective case-control study of term neonates (2013-2020).
  • Cases: genetic epilepsy, normal MRI, no confounding conditions. Controls: healthy, normal MRI.
  • Diffusion Tensor Imaging (DTI) assessed white matter using fractional anisotropy (FA) and mean diffusivity (MD) via Tract Based Spatial Statistics (TBSS).

Main Results:

  • Fifty-eight neonates (19 cases, 39 controls) were analyzed.
  • Significantly increased FA and decreased MD observed in the superior corona radiata of neonates with genetic epilepsy versus controls.
  • Other association tracts showed trends toward significance; no correlation found between FA/MD and seizure burden or outcome.

Conclusions:

  • Neonates with genetic epilepsy exhibit altered white matter microstructure (higher FA, lower MD) in major association tracts.
  • These findings demonstrate early white matter impact in neonatal epilepsies.
  • Early-onset seizures have a global effect on developing white matter in neonates.