Related Experiment Video
Updated: May 25, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Multiparametric functional MRI for early detection of renal impairment: clinical applications and future directions
Jiangyue Yang1,2, Jiayi Chen1,2, Shasha Zhang3
1Department of Graduate School, Zunyi Medical University, Zunyi, China.
Abstract:
Early identification of renal impairment is critical for improving patient outcomes. Most current biochemical markers of renal function are not sensitive enough to detect early changes in kidney function. Functional magnetic resonance imaging (fMRI) is a new technique that is not only non-invasive (it does not use ionizing radiation) but also provides very high-resolution images of soft tissue. fMRI can measure a variety of parameters related to renal function, including renal perfusion, oxygenation, water-molecule diffusion, and microstructural changes, enabling a comprehensive multiparametric assessment of renal function that may lead to earlier detection of renal impairment. This review provides a systematic analysis of the multiparametric fMRI techniques available for assessing early renal impairment, including the principles of diffusion-weighted imaging (DWI) and its derivatives; blood-oxygen-level-dependent (BOLD) imaging ; arterial spin labeling (ASL); and relaxometry (T1/T2 mapping). It elaborates on their application progress in the early identification of acute kidney injury (AKI), chronic kidney disease (CKD), diabetic kidney disease (DKD), and renal allograft injury. The review objectively analyzes the current limitations and controversies of these technologies and discusses future directions that integrate artificial intelligence (AI) and multimodal fusion. This review aims to equip radiologists and clinicians with the knowledge to make more informed, precise, and timely decisions in the management of early renal impairment.
Related Concept Videos
Imaging Studies IV: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Imaging Studies I: Kidney, Ureter, and Bladder Studies
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Imaging Studies VII: Vascular Imaging

