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Updated: May 25, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Selective subperineurial dissection in vestibular schwannoma surgery: how I do it
Taichi Sayanagi1, Ryota Tamura2, Takayuki Ohira1
1Department of Neurosurgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
Background:
The dissection plane in vestibular schwannoma surgery significantly influences facial and cochlear nerve outcomes. Although histological studies demonstrate that the "tumor capsule" represents vestibular nerve perineurium, epicapsular dissection along its outer surface remains prevalent in clinical practice.
Method:
We describe subperineurial dissection, removing tumor from beneath the perineurium while preserving this protective layer on the facial and cochlear nerves. Key steps include early internal auditory canal drilling and identification of the true perineurial plane.
Conclusion:
Subperineurial dissection prioritizes nerve function over radical resection, achieving high rates of facial nerve preservation with acceptable tumor control.