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Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:

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Related Experiment Video

Updated: May 25, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Development of a Simple Clinical Risk Score for Mortality Prediction in Neonatal Gram-Negative Sepsis.

Akanksha Verma1, Richa Sinha2,3, Surabhi Periwal4,5

  • 1Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 226014, India. Akanksha.ve@gmail.com.

Indian Journal of Pediatrics
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) ≥ Stage II, refractory shock, and leukopenia are key predictors of mortality in neonates with Gram-negative sepsis. A new Neonatal Risk Scoring System (NRSS) aids in early risk stratification for these vulnerable infants.

Keywords:
Gram-negative bacteriaMortalityNECNeonatal sepsisRisk factor

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Last Updated: May 25, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
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Published on: January 27, 2019

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Clinical Risk Stratification

Background:

  • Gram-negative sepsis poses a significant threat to neonates.
  • Identifying predictors of mortality is crucial for timely intervention.

Purpose of the Study:

  • To identify clinical and laboratory predictors of mortality in neonates with Gram-negative sepsis.
  • To develop a simple bedside risk score for early risk stratification.

Main Methods:

  • A cohort of 50 neonates with Gram-negative sepsis was studied.
  • Logistic regression and LASSO identified independent predictors of mortality.
  • A Neonatal Risk Scoring System (NRSS) was developed based on these predictors.

Main Results:

  • Mortality rate was 38%.
  • Necrotizing enterocolitis (NEC) ≥ Stage II, refractory shock, and leukopenia independently predicted mortality.
  • The NRSS demonstrated excellent discrimination (AUC > 0.9) with a cut-off ≥ 7 predicting mortality with high sensitivity and specificity.

Conclusions:

  • NEC ≥ Stage II, refractory shock, and leukopenia are significant independent predictors of mortality in neonatal Gram-negative sepsis.
  • The NRSS is a reliable and simple tool for early risk stratification of neonates at risk.