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Related Experiment Video

Updated: May 25, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Diffuse splenic calcifications in systemic lupus erythematosus: a case-based review.

Celine Tack^1,2, Ann Stuer³, Jean-Baptiste Vulsteke^3,4

¹Department of Rheumatology, AZ Delta, Roeselare, Roeselare, Belgium. celine.tack@student.kuleuven.be.

Rheumatology International

|May 23, 2026

Summary

Splenic calcifications, a rare finding in systemic lupus erythematosus (SLE), can be an early sign of this autoimmune disease. Imaging reveals diffuse microcalcifications, aiding SLE diagnosis and management.

Keywords:

Calcinosis Incidental findings Lupus erythematosus Spleen Systemic

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Last Updated: May 25, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Published on: June 16, 2020

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Rheumatology
Radiology
Pathology

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder affecting multiple organs.
Splenic involvement in SLE is diverse, with splenic calcifications being a rare but increasingly noted manifestation.
Recognizing specific imaging patterns is crucial for early diagnosis and management.

Purpose of the Study:

To highlight splenic calcifications as a potential presenting sign of SLE.
To characterize the typical imaging findings of splenic calcifications in SLE patients.
To synthesize existing literature on splenic calcifications in SLE to aid clinical interpretation.

Main Methods:

A case report of a patient with fever and splenic microcalcifications leading to SLE diagnosis.
A systematic literature review of 29 previously reported cases of splenic calcifications in SLE.
Analysis of clinical, serological, and imaging data from 30 total cases.

Main Results:

A characteristic imaging pattern of diffuse, small, round-to-rod-shaped splenic calcifications was identified.
No distinct serological or clinical phenotype was associated with splenic calcifications in SLE.
Calcifications were generally stable but could progress with disease flares, sometimes leading to functional asplenia.

Conclusions:

Splenic calcifications can be an early or presenting manifestation of SLE.
Incidental detection of splenic calcifications warrants consideration of SLE in the differential diagnosis.
This review provides an updated overview to enhance clinical awareness and interpretation of splenic calcifications in SLE.