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Related Concept Videos

Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Perilipin-2-Anchored Lipid Droplet-Targeting Phototheranostics.

Lipeng Zhang1, Jiyoung Yoo2, Juan Bai1

  • 1Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Biomedical and Health Laboratory in Shanxi Province, Research Institute of Applied Chemistry, Shanxi University, Taiyuan, China.

Angewandte Chemie (International Ed. in English)
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces C-BDP-OMe, a novel lipid droplet-targeting agent for precise cancer therapy. It effectively suppresses tumors via photothermal ablation, minimizing off-target damage and activating apoptosis and ferroptosis.

Keywords:
coumarin‐fused BODIPYdual‐anchoringfluorescence imaginglipid dropletsphotothermal therapy

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Published on: September 17, 2013

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Conventional photothermal agents cause off-target damage due to non-specific uptake by normal cells.
  • Lipid droplets (LDs) are abundant in tumor cells, presenting a potential target for selective drug delivery.
  • Targeting subcellular organelles like LDs offers a strategy for precise cancer theranostics.

Purpose of the Study:

  • To develop and evaluate a novel LD-targeted theranostic agent, C-BDP-OMe, for enhanced cancer therapy.
  • To investigate the dual-anchoring strategy for specific accumulation in LD-rich tumor cells.
  • To assess the therapeutic efficacy and mechanism of C-BDP-OMe in tumor suppression.

Main Methods:

  • Designed C-BDP-OMe with an extended conjugated system and coumarin-fused BODIPY scaffold for NIR optical properties.
  • Employed a dual-anchoring strategy combining "like dissolves like" and PLIN2 protein docking for LD targeting.
  • Evaluated photothermal performance, fluorescence behavior, and in vivo tumor suppression efficacy.
  • Investigated the cell death pathways (apoptosis and ferroptosis) induced by C-BDP-OMe.

Main Results:

  • C-BDP-OMe demonstrated excellent photothermal conversion efficiency (62.6%) and localized photothermal ablation.
  • The agent exhibited turn-on fluorescence with a high signal-to-noise ratio under no-wash conditions.
  • Effective tumor suppression was achieved with minimal systemic side effects.
  • Therapeutic mechanism involved concurrent activation of apoptosis and ferroptosis.

Conclusions:

  • C-BDP-OMe is a potent LD-targeted theranostic agent for precise cancer treatment.
  • Subcellular organelle-level targeting enhances therapeutic specificity and efficacy.
  • Exploiting microenvironmental features like LDs is crucial for next-generation anticancer theranostic design.