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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...

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Updated: May 25, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Pustular Dermatoses. Part II. Infectious, Genetic, and Transient Neonatal.

Suyeon Hong1, Kailyn Valido1, Richard Antaya1

  • 1Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.

Journal of the American Academy of Dermatology
|May 23, 2026
PubMed
Summary
This summary is machine-generated.

Pustular dermatoses are diverse skin conditions with many causes. This review covers their epidemiology, pathogenesis, diagnosis, and management, with Part II focusing on specific types.

Keywords:
geneticinfectiousneonatalpustulosis

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Area of Science:

  • Dermatology
  • Immunology
  • Pathophysiology

Background:

  • Pustular dermatoses encompass a wide spectrum of inflammatory, autoimmune, infectious, and genetic conditions.
  • These conditions present unique clinical features and pathophysiological mechanisms.
  • Accurate diagnosis is crucial for effective management in dermatologic practice.

Purpose of the Study:

  • To provide an up-to-date overview of pustular dermatoses within a continuing medical education framework.
  • To enhance practitioners' understanding of the epidemiology, pathogenesis, clinical presentations, and diagnostic approaches.
  • To highlight emerging management strategies and recent advancements in the field.

Main Methods:

  • Literature review and synthesis of current research on pustular dermatoses.
  • Focus on epidemiological data, etiological factors, and clinical characteristics.
  • Discussion of diagnostic tools and therapeutic interventions.

Main Results:

  • Pustular dermatoses are heterogeneous, requiring a broad differential diagnosis.
  • Understanding pathophysiology aids in clinical differentiation and management.
  • Advances in diagnostics and therapeutics are improving patient outcomes.

Conclusions:

  • This article offers a comprehensive review of pustular dermatoses, aiding in differential diagnosis and management.
  • Practitioners will gain insights into the latest developments in understanding and treating these conditions.
  • Part II will further explore infectious, genetic, and neonatal pustular eruptions.