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Evidence and Consensus-Based Guidelines in Vogt-Koyanagi-Harada Disease. Multimodal Imaging in Uveitis (MUV)
Peizeng Yang1, Lan Xia2, Aniruddha Agarwal3
1Ophthalmology Medical Center, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, China.
Ophthalmology. Retina
|May 23, 2026
Summary
Multimodal imaging, including color fundus photography (CFP) and optical coherence tomography (OCT), aids in diagnosing Vogt-Koyanagi-Harada disease (VKH). These advanced techniques improve disease activity assessment and complication detection for better patient outcomes.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Vogt-Koyanagi-Harada (VKH) disease is a multisystem inflammatory disorder affecting ocular and neurological tissues.
- Accurate diagnosis and monitoring of VKH disease activity and complications are crucial for preventing vision loss.
Purpose of the Study:
- To establish consensus-based guidelines for using multimodal imaging in diagnosing and managing Vogt-Koyanagi-Harada disease (VKH).
- To define imaging criteria for assessing VKH disease activity and detecting associated complications.
Main Methods:
- A systematic literature review and nominal group technique (NGT) involving international uveitis and retina specialists.
- Expert panel reviewed cases using color fundus photography (CFP), optical coherence tomography (OCT), fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and OCT angiography (OCTA).
Main Results:
- Consensus identified key multimodal imaging features for active VKH diagnosis, including serous detachments (CFP, OCT) and choroidal thickening (OCT).
- OCT and ICGA demonstrated high sensitivity in detecting disease activity and subclinical reactivation.
- Multimodal imaging is vital for assessing disease activity and detecting complications like subretinal fibrosis and choroidal neovascularization (CNV).
Conclusions:
- Integrating multimodal imaging (CFP, OCT, ICGA) enhances diagnostic accuracy and disease activity assessment in VKH.
- These guidelines provide a framework for optimal imaging use, aiding in early detection of vision-threatening VKH complications.
- The recommendations may inform future refinements of diagnostic criteria for VKH disease.
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