Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 25, 2026

Live Imaging and Characterization of Microglia Dynamics in the Zebrafish Embryo
07:45

Live Imaging and Characterization of Microglia Dynamics in the Zebrafish Embryo

Published on: May 17, 2024

Microglial ontogeny and in vitro reconstruction: Bridging development and modeling.

Mizuki Ono1, Hinako Matsuo1, Yuki Hattori1

  • 1Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.

Neuroscience Research
|May 23, 2026
PubMed
Summary

Microglia, the brain's immune cells, originate from yolk sac progenitors and mature within the central nervous system (CNS). Researchers are advancing in vitro models to study microglial development and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facilitatory effects of LY404187, a positive allosteric modulator of AMPA receptors, on swallowing initiation in anesthetized male rats.

Archives of oral biology·2026
Same author

Real-world outcomes after switching to faricimab in treatment-resistant diabetic macular edema: A 1-year observational study with choroidal thickness assessment.

PloS one·2026
Same author

Enhanced engraftment of transplanted microglia through host microglia depletion in the embryonic brain.

Neuroscience research·2026
Same author

Early Postpartum Screening: Predictive Value of Edinburgh Postnatal Depression Scale (EPDS) Scores on Day 3 for Depression at One Month.

Cureus·2025
Same author

Meflin/ISLR is a meningeal cell-specific marker involved in the development of meninges and meningioma progression.

Brain pathology (Zurich, Switzerland)·2025
Same author

Short-Term Efficacy of Two-Step Treatment of Retinopathy of Prematurity in a Japanese Cohort: Anti-VEGF Therapy Followed by Routine Laser Photocoagulation.

Journal of clinical medicine·2025

Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience
  • Stem Cell Biology

Background:

  • Microglia are unique CNS immune cells with a distinct yolk sac origin.
  • Their development involves colonization, differentiation, and maturation influenced by the brain microenvironment.
  • Understanding microglial ontogeny is crucial for central nervous system (CNS) research.

Purpose of the Study:

  • To review the molecular and developmental mechanisms of microglial ontogeny.
  • To discuss the advancements and applications of in vitro models for studying microglia.
  • To highlight how integrated knowledge refines experimental systems for human disease research.

Main Methods:

  • Review of current literature on microglial development and in vitro models.
Keywords:
BrainCultureDevelopmentDifferentiationMacrophageMicrogliaOrganoidiPSC

More Related Videos

Derivation of a Human Brain Organoid with Microglia Development
10:34

Derivation of a Human Brain Organoid with Microglia Development

Published on: January 17, 2025

Related Experiment Videos

Last Updated: May 25, 2026

Live Imaging and Characterization of Microglia Dynamics in the Zebrafish Embryo
07:45

Live Imaging and Characterization of Microglia Dynamics in the Zebrafish Embryo

Published on: May 17, 2024

Derivation of a Human Brain Organoid with Microglia Development
10:34

Derivation of a Human Brain Organoid with Microglia Development

Published on: January 17, 2025

  • Analysis of progenitor specification, brain colonization, and maturation processes.
  • Evaluation of human induced pluripotent stem cell (iPSC)-derived microglia and organoid models.

    • Main Results:

    • Significant progress in elucidating microglial developmental pathways.
    • Development of diverse in vitro systems, including iPSC-derived microglia, for disease modeling.
    • Enhancement of physiological relevance through transplantation and organoid models.

    Conclusions:

    • In vitro models offer powerful, complementary platforms for studying microglial biology.
    • Integrating developmental knowledge with in vitro systems advances CNS disease research.
    • Further refinement of experimental systems is key to understanding microglial roles in health and disease.