Related Experiment Video
Updated: May 25, 2026

05:34
Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
Published on: June 6, 2025
Development and Validation of a Sensitive Search Strategy for Pharmacy Education
Hilary Jasmin1, Krystal Bullers2, Deborah D Divis3
1Center for Evidence-based Policy, Portland, Oregon, USA.
American Journal of Pharmaceutical Education
|May 23, 2026
Summary
A validated search hedge was developed for pharmacy education research, ensuring efficient and precise evidence synthesis. This tool achieves 100% relative recall across multiple databases.
Area of Science:
- Pharmacy Education Research
- Information Science
Background:
- Efficient evidence synthesis is crucial for advancing pharmacy education.
- Developing comprehensive search strategies is key to accurate literature retrieval.
Purpose of the Study:
- To develop and validate a comprehensive search hedge for pharmacy education research.
- To support efficient and precise evidence synthesis in this field.
Main Methods:
- A sensitive search hedge was created and refined using primary studies from high-quality systematic reviews.
- Relative recall methodology was employed with a corpus of 100 PubMed identifiers (PMIDs) for validation.
- The search hedge was translated and re-validated for Embase and MEDLINE databases.
Main Results:
- The developed search hedge achieved 100% relative recall in Embase, MEDLINE via Ovid, and MEDLINE via EBSCO.
- The validation process confirmed the hedge's high sensitivity and accuracy.
Conclusions:
- Expert-driven relative recall methodology yielded a highly sensitive and validated search hedge.
- This validated hedge reliably identifies relevant literature for pharmacy education researchers.
- The methodology is adaptable for other pharmacy research and health science disciplines.
Related Concept Videos
Structure-Activity Relationships and Drug Design
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmaceutical Poisoning: Potential Scenarios
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Pharmacovigilance
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
