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Updated: May 25, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
Published on: November 24, 2020
Severe hypertriglyceridemia due to heterozygous LPL variant, ApoE ε2ε2 genotype, and environmental interactions in an
Don P Wilson1, Amelia Vinson1, Kacey Lewis1
1Department of Pediatric Endocrinology and Diabetes, Cook Children's Medical Center, Fort Worth, TX, USA (Wilson, Vinson, and Lewis).
Abstract:
Severe hypertriglyceridemia in children is uncommon and typically results from a combination of acquired and genetic factors. We report the case of an 11-year-old boy with triglyceride levels exceeding 1700 mg/dL secondary to obesity, medication effects, and rare genetic variants. This case highlights the importance of early recognition, comprehensive evaluation, and evidence-based management to prevent acute complications such as pancreatitis and, in adulthood, premature cardiovascular disease.
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