Subject: Author response to "Comment on 'Identification of the molecular characterization and tumor microenvironment of thoracic inflammatory myofibroblastic tumors"' (JFMA-D-26-00819)
Related Experiment Video
Updated: May 25, 2026

05:00
Multiplex Immunohistochemistry Staining for Paraffin-embedded Lung Cancer Tissue
Published on: November 21, 2023
Yen-Lin Huang1, Chia-Chi Hsu2, Shang-Gin Wu3
1Department of Pathology, National Taiwan University Cancer Center, National Taiwan University, Taipei, Taiwan.
Abstract
No abstract available in PubMed .
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The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
