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Updated: May 26, 2026
08:19
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Nitration in cancer signaling
Inge Claassen1, Nirbachita Adrita1, Kevin B Chandler2
1Center for Translational Science, Florida International University, Port St. Lucie, Florida, 34987, USA; Department of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida, 34987, USA.
Redox Biology
|May 24, 2026
Summary
Oxidative stress, driven by reactive oxygen and nitrogen species, fuels cancer progression. Protein tyrosine nitration, a key modification, actively promotes malignancy and offers new therapeutic targets.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Oxidative stress, an imbalance of reactive oxygen and nitrogen species (ROS/RNS), disrupts cellular functions.
- In cancer, ROS/RNS dysregulation promotes tumor initiation and progression.
- Nitric oxide (NO) and peroxynitrite (ONOO-) are key RNS mediators in the tumor microenvironment.
Purpose of the Study:
- To review the molecular mechanisms of oxidative stress in cancer.
- To emphasize the role of protein tyrosine nitration in oncogenic signaling.
- To explore the impact of nitration on cancer hallmarks and therapeutic potential.
Main Methods:
- Literature review focusing on oxidative stress and protein modifications.
- Analysis of molecular mechanisms linking RNS to cancer signaling pathways.
- Examination of evidence for protein nitration in promoting malignancy.
Main Results:
- Protein tyrosine nitration alters protein structure, function, and interactions.
- Selective nitration of signaling proteins drives multiple hallmarks of cancer.
- Nitrated proteins actively contribute to tumor initiation, progression, and immune evasion.
Conclusions:
- Nitrated proteins are active effectors, not just byproducts, of tumorigenesis.
- Protein tyrosine nitration represents a source of cancer biomarkers.
- Targeting protein nitration offers potential for novel cancer therapies.
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