Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Corpus luteum function in ageing inbred mice.

R G Gosden, R E Fowler

|January 15, 1979

Summary

This summary is machine-generated.

Aging female mice show reduced breeding success due to fewer ovulations and higher embryo mortality. Despite this, progesterone levels in aged mice remain comparable to younger mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to 'Ovarian function 6 years after cryopreservation and transplantation of whole sheep ovaries' [Reproductive BioMedicine Online 34 (2010) 48-52.

Reproductive biomedicine online·2017

Same author

In situ identification of follicles in ovarian cortex as a tool for quantifying follicle density, viability and developmental potential in strategies to preserve female fertility.

Human reproduction (Oxford, England)·2010

Same author

Ovarian function 6 years after cryopreservation and transplantation of whole sheep ovaries.

Reproductive biomedicine online·2010

Same author

The oocyte population is not renewed in transplanted or irradiated adult ovaries.

Human reproduction (Oxford, England)·2008

Same author

A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation.

Human reproduction (Oxford, England)·2008

Same author

Prevalence of premature ovarian failure in monozygotic and dizygotic twins.

Human reproduction (Oxford, England)·2006

Area of Science:

Reproductive biology
Gerontology
Mouse models in research

Background:

Female reproductive capacity declines with age.
Aging is associated with reduced fertility and increased pregnancy complications.

Purpose of the Study:

To investigate the reproductive performance of aged female mice.
To determine if progesterone levels are altered in aged female mice with impaired breeding.

Main Methods:

Comparative analysis of reproductive parameters in aged versus young female mice.
Radioimmunoassay (RIA) was used to quantify progesterone levels in serum, corpora lutea, and uterine flushings.

Main Results:

Aged female mice exhibited impaired breeding performance characterized by a reduced number of ovulations.

Related Experiment Videos

Increased mortality of embryos was observed in aged female mice.

Progesterone concentrations in sera, corpora lutea, and uterine flushings were similar between aged and young female mice.

Conclusions:

The impaired breeding performance in aged female mice is not attributable to reduced progesterone levels.
Other factors beyond progesterone likely contribute to the reproductive decline observed in aging female mice.