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Published on: February 22, 2018
Association between C-reactive protein to lymphocyte ratio and depression: A population-based study.
Ziyang Zheng1, Jiaqi Wu2, Qinyang Shi3
1Department of Stomatology, The Third People's Hospital of Yibin, Yibin 644000, Sichuan, China.
Summary
Elevated C-reactive protein to lymphocyte ratio (CLR) is linked to increased depression risk and suicidal ideation. This accessible biomarker may aid early detection and management of depressive symptoms.
Area of Science:
- Biomarkers and Disease Risk
- Public Health and Epidemiology
- Mental Health Research
Background:
- The C-reactive protein to lymphocyte ratio (CLR) is an emerging biomarker associated with various diseases.
- Investigating CLR's role in depression risk and suicidal ideation is crucial for public health.
- Utilizing large-scale population data enhances the reliability of biomarker association studies.
Purpose of the Study:
- To investigate the association between the C-reactive protein to lymphocyte ratio (CLR) and depressive symptoms.
- To explore the relationship between CLR and suicidal ideation in a large population sample.
- To evaluate CLR as a potential biomarker for early depression detection.
Main Methods:
- A population-based study using National Health and Nutrition Examination Survey (NHANES) data from 2015-2023.
- Assessed depressive symptoms and suicidal ideation using the Patient Health Questionnaire-9 (PHQ-9).
- Employed multivariable weighted logistic and linear regression models to analyze the relationship between Ln-CLR and depression, with sensitivity analyses.
Main Results:
- A significant positive association was observed between elevated Ln-CLR levels and depressive symptoms.
- Higher CLR levels were associated with increased odds of depressive symptoms (OR=1.12, P=0.014) and suicidal ideation.
- Sensitivity analyses confirmed the robustness of the findings, supporting CLR as a reliable indicator.
Conclusions:
- Elevated CLR is significantly associated with an increased risk of depressive symptoms and suicidal ideation.
- CLR shows potential as a novel and accessible biomarker for early depression detection.
- Findings support the utility of CLR in managing and identifying individuals at risk for depression.
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