Evaluation of open field movement organization and spatial orientation in 5xFAD mice

Wandering behavior or becoming lost in familiar environments is frequently observed during progression of Alzheimer's Disease (AD) and may be a possible prodromal symptom of the disease but also is extremely dangerous for those suffering from this neurodegenerative disease. The accumulation of amyloid-beta peptide (Aβ) has been implicated in the neuropathology and cognitive deficits associated with AD. This study investigated changes in open field movement organization in a 5xFAD mouse model of AD that and the deposition of amyloid pathology. Mouse open field behavior was collected under dark and light conditions at three, six, nine, and twelve months of age. The resulting pattern of genotype differences consisted of a motor deficit rather than impaired use of self-movement or environmental cues. This work establishes a foundation for future studies to investigate the efficacy of therapeutic interventions.