Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipoprotein(a) testing in invasive coronary angiography: Screening yield and anatomic coronary disease burden.

Cardiovascular revascularization medicine : including molecular interventions·2026
Same author

Outcomes of cannulation strategies under antegrade cerebral perfusion in type a aortic dissection surgery: a systematic review and meta-analysis.

Journal of cardiothoracic surgery·2026
Same author

Medium-term outcomes of aortic valve-sparing procedure in trileaflet valve: Longitudinal analysis from the Heart Valve Society Registry.

JTCVS structural and endovascular·2026
Same author

In Vitro Tests of Antegrade Distal Limb Perfusion Modalities in Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same author

Self-Reported Quality of Life and 30-Day Mortality in Elective Cardiac Surgery.

JACC. Advances·2026
Same author

Aortic homografts for native and prosthetic aortic valve and root endocarditis: Results from the EUropean REgistry of Cryopreserved Aortic Homografts EURECAH.

The Journal of thoracic and cardiovascular surgery·2026
Same journal

Mitral valve anomalies in transposition of the great arteries.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Association between interventional cardiologist practice characteristics, CABG use, and clinical outcomes.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Robotic-Assisted Paediatric Lung Anatomical Resection: A Safe Alternative to Thoracotomy in Children's Complex Cases.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Impact of Transcatheter or Surgical Mitral Repair on Arrhythmic Burden in Patients With Mitral Valve Prolapse.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Quality of Life After Cardiac Surgery: The QUACS Study and Benefit Prediction Model.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Ventricular free-wall rupture, ventricular pseudoaneurysm, and papillary muscle rupture complicating acute myocardial infarction.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Valve-sparing Aortic Root Replacement: Defining High-volume Centres Using Prospective Data.

Pascal J Govers1, Michal J Kawczynski2,3, Samuel Heuts2,3

  • 1Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, 3015GD, The Netherlands.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|May 24, 2026
PubMed
Summary
This summary is machine-generated.

Performing at least 12 valve-sparing aortic root replacements annually defines a high-volume center, improving long-term valve durability and survival. Early outcomes are less sensitive to case volume.

Keywords:
annual case volumeaortic root surgeryoptimal case volumereimplantation techniquevalve-sparing operationsvolume-outcome association

More Related Videos

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

Related Experiment Videos

Last Updated: May 26, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Cardiac Surgery Outcomes

Background:

  • Valve-sparing aortic root replacement (VSARR) is complex, with variable institutional volumes.
  • Establishing expertise thresholds for VSARR centers is challenging.
  • Defining high-volume centers is crucial for quality improvement.

Purpose of the Study:

  • To identify an optimal annual case volume for high-volume centers performing VSARR.
  • To analyze the relationship between institutional volume and patient outcomes for VSARR.
  • To establish a benchmark for VSARR center expertise.

Main Methods:

  • Retrospective analysis of 2,668 elective VSARR cases from the Heart Valve Society Aortic Valve database.
  • Primary early outcome: 30-day composite of mortality, thromboembolism, reintervention, conversion, and regurgitation.
  • Primary long-term outcome: freedom from aortic valve reintervention.
  • Volume-outcome association modeled using restricted cubic splines and the elbow method.
  • Analyses adjusted for EuroSCORE II.

Main Results:

  • No significant association between annual volume and early composite outcomes (p=0.8003).
  • Significant non-linear association between volume and long-term aortic valve reintervention-free survival (p=0.0023).
  • Improved long-term outcomes observed in centers performing ≥12 VSARR cases annually (95% CI: 10-12).
  • Results confirmed in sensitivity analyses (p<0.0001).

Conclusions:

  • An annual institutional volume of ≥12 VSARR procedures is associated with enhanced long-term valve durability and survival.
  • Early postoperative outcomes are less dependent on annual case load due to low event rates.
  • This high-volume threshold can serve as a benchmark for experienced cardiac surgery centers and guide quality initiatives.