Related Experiment Video
Updated: May 26, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
IgG4-related Disease Affecting Multiple Organs Despite Normal Serum IgG4 Levels
Takahiro Kida1, Kentaro Watanabe1, Mana Nishikawa1
1Department of Nephrology, Kurashiki Central Hospital, Japan.
Abstract:
IgG4-related disease (IgG4-RD) is characterized primarily by elevated serum IgG4 levels and it can affect multiple organs. We herein present a case of IgG4-RD affecting the kidneys, right submandibular gland, lungs, mediastinal lymph nodes, and retroperitoneum, despite normal serum IgG4 levels. In this case, a histopathological examination of the kidneys and submandibular glands revealed marked lymphoplasmacytic infiltration and a relatively small number of IgG4-positive plasma cells. The patient was diagnosed with IgG4-RD and showed a favorable response to corticosteroid therapy. This case highlights the importance of a histopathological evaluation for diagnosing IgG4-RD, particularly in patients with normal serum IgG4 levels.
More Related Videos
06:35An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
14:18Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
Published on: October 13, 2023
Related Concept Videos
Graves' Disease I: Introduction
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Graves Disease II: Pathophysiology
Inflammatory Bowel Disease III: Crohn's Disease
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Hypersensitivity Reactions: Immune-Complex Reactions