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Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project PAIR-PSP)
Prashanth Lingappa Kukkle1, Divyani Garg2, Jacky Ganguly3
1Parkinson's Disease and Movement Disorders Clinic, Bangalore, India.
Movement Disorders Clinical Practice
|May 24, 2026
Summary
This study profiles the largest Indian cohort of Progressive Supranuclear Palsy (PSP) patients, revealing diverse clinical presentations and limited treatment benefits. Findings support future genetic and longitudinal research in varied populations.
Area of Science:
- Neurology
- Neuroscience
- Genetics
Background:
- Progressive Supranuclear Palsy (PSP) is a rare, aggressive tauopathy with limited global data.
- India's genetic diversity necessitates large datasets for comprehensive PSP understanding.
Purpose of the Study:
- To characterize the demographic, clinical, and phenotypic profiles of a large, multicenter Indian PSP cohort.
Main Methods:
- Prospective recruitment of 1035 subjects meeting MDS-PSP criteria across Indian movement disorder centers (2021-2025).
- Standardized collection of demographic and clinical data.
Main Results:
- The cohort (M:F=709:326) had a median age of 65 years; PSP-Richardson's syndrome was most common (41%).
- Distinct progression patterns observed across phenotypes (e.g., PSP-PGF, PSP-SL, PSP-P).
- Limited subjective benefit reported from Levodopa (21% >25%) and Amantadine (177/351 improved).
Conclusions:
- The largest systematically profiled PSP cohort reveals shared and unique features, including frequent non-Richardson's Syndrome variants and aggressive disease courses.
- Better survival noted in PSP-Parkinsonism, alongside limited pharmacological benefits.
- Establishes a foundation for future longitudinal and genetic studies in diverse populations.
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