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Updated: May 26, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Epidemiological and Clinical Profile of Young Patients With Head and Neck Cancer: A Retrospective Analysis
Maxilaine de Lima Vaz Ferreira1, Ana Carolina Ribeiro de Oliveira2, Fabrizio Dos Santos Cardoso2,3
1Centro Universitário FAMINAS, Muriaé, MG, Brazil.
Abstract:
Squamous cell carcinoma of the head and neck (HNSCC) is a global public health issue. Traditionally diagnosed in individuals over 60 years old, there has been a rising incidence among young patients (< 45 years). This retrospective and descriptive study analyzes the epidemiological, clinical, and biochemical profiles of young patients diagnosed with HNSCC between 2015 and 2022 at the Cancer Hospital of Muriaé, Minas Gerais, Brazil. A comparative analysis between young and older patients revealed significant differences in inflammatory profiles and disease progression. Young patients showed higher counts of leukocytes, monocytes, and neutrophils compared to older patients, suggesting an exacerbated inflammatory response. The 60-month survival rate was 41.5% among young patients and 38.1% among older ones, with no statistically significant difference. A strong association between poor oral hygiene and HNSCC was observed, with 61.43% of young patients presenting poor hygiene-a factor that may contribute to increased local inflammation and tumor progression. These findings underscore the need for preventive strategies and early diagnosis.
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