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Updated: May 26, 2026

Teratoma Generation in the Testis Capsule
Published on: November 7, 2011
Growing teratoma syndrome of the ovary: a case series
Mpokigwa Kiputa1, Tariq Aziz2, Advera Ngaiza3
1Department of Paediatrics and Child Health, School of Medicine, Muhimbili University of Health and Allied Sciences, Upanga West, 9 United Nations Road, P.O. Box 65001, Dar Es Salaam, Tanzania. mpokigwakiputa@gmail.com.
Background:
Growing teratoma syndrome (GTS) is a rare clinical phenomenon characterized by an enlarging tumor during or after completion of therapy for a germ cell tumor.
Case Presentation:
We report two Black African females, aged 10 and 12 years, with an initial diagnosis of malignant ovarian tumor with elevated alpha-fetoprotein (AFP) and B-human chorionic gonadotropin (B-HCG). After initiation of chemotherapy, the tumors progressed while the tumor markers continued to decline. Subsequent removal of the tumors showed mature teratoma with no malignant components.
Conclusion:
GTS is often mistaken for disease progression. High index of suspicion is required when an abdominal germ cell tumor progresses on therapy with declining tumor markers.
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