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Oncogenic Role of SRPK2 in Different Types of Cancer: A Systematic Review

Samuel Inácio da Silva Paiva1, Bárbara Braga Ferreira1, Alexandre Martins Oliveira Portes2

  • 1Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.

Journal of Cellular and Molecular Medicine
|May 25, 2026
PubMed

Insights

Serine/arginine protein kinase 2 (SRPK2) promotes cancer development and metastasis through alternative splicing and signaling pathways. Targeting SRPK2 shows therapeutic potential and indicates its role as a cancer biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Serine/arginine protein kinase 2 (SRPK2) is implicated in cellular processes.
  • Its specific roles in tumorigenesis and metastasis require comprehensive evaluation.

Purpose of the Study:

  • To systematically review the evidence on the tumorigenic and metastatic roles of SRPK2 in various cancers.
  • To explore the underlying mechanisms and therapeutic potential of targeting SRPK2.

Main Methods:

  • Systematic review of preclinical studies.
  • Analysis of studies focusing on SRPK2's involvement in cancer signaling, prognosis, and metastatic phenotypes.
  • Evaluation of preclinical data on SRPK2 inhibition.

Main Results:

  • SRPK2 promotes cancer development via alternative splicing and diverse signaling pathways.
  • Elevated SRPK2 expression correlates with poor clinical outcomes in multiple malignancies.
  • Inhibition of SRPK2 demonstrates antitumor and antimetastatic effects in preclinical models.

Conclusions:

  • SRPK2 is a significant driver of oncogenesis and metastasis.
  • SRPK2 represents a promising therapeutic target for cancer treatment.
  • SRPK2 holds potential as a predictive biomarker for cancer prognosis.
Keywords:
cancermetastasisserine/arginine protein kinase 2 (SRPK2)targeted therapytumour

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