Related Experiment Video
Updated: May 26, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three Meroterpenes From the Mangrove Endophytic Fungus Phyllosticta sp. E2A1
Mei Wang1, Shang-Wen Chen1, Xi-Kang Zheng2,3
1School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Abstract:
Two new monoterpene-shikimate-conjugated meroterpenes, named phyllostictones J (1) and K (2), were isolated from the mangrove endophytic fungus Phyllosticta sp. E2A1, together with a new sesquiterpene-shikimate-conjugated spirocyclic meroterpene, named capitalensis E (3). The structures of 1-3 were elucidated by nuclear magnetic resonance spectroscopy (NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), single-crystal x-ray diffraction analysis, electronic circular dichroism (ECD) calculations, and modified Mosher's method. Compounds 1-3 were evaluated for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Among them, compound 2 exhibited inhibitory activity with an IC50 value of 10.8 µM.
More Related Videos
Related Concept Videos
Antifungal Agents
Bacterial Phylum Planctomycetes
Microbe-Plant Interactions
Epiphytes, Parasites, and Carnivores
Bacterial Phylum Tenericutes

