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Updated: May 26, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

White Matter Microstructural Injury in Patients With Acute Single Subcortical Infarction: A Preliminary Tract-Based

Zilong Zhu1, Tianyi Shen2, Junfeng Xiong1

  • 1Department of Acupuncture and Moxibustion, Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210017, Jiangsu, China, njucm.edu.cn.

Neural Plasticity
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

This study reveals white matter (WM) damage in acute single subcortical infarction (ASSI) patients using advanced imaging. The findings link microstructural changes to motor function deficits, aiding in clinical assessment.

Keywords:
Atlas-Based AnalysisTract-Based Spatial StatisticsWallerian degenerationacute single subcortical infarction

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Last Updated: May 26, 2026

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Published on: September 25, 2019

Area of Science:

  • Neuroimaging
  • Cerebrovascular Diseases
  • White Matter Integrity

Background:

  • Acute Single Subcortical Infarction (ASSI) is common, yet early white matter (WM) damage patterns are unclear.
  • Understanding WM microstructural changes is crucial for ASSI patient management.
  • This study investigates early WM alterations in ASSI.

Purpose of the Study:

  • To examine WM microstructural alterations in ASSI patients.
  • To evaluate the combined utility of Tract-Based Spatial Statistics (TBSS) and Atlas-Based Analysis (ABA) for ASSI.
  • To correlate WM changes with motor function deficits.

Main Methods:

  • Prospective study with 20 ASSI patients and 24 healthy controls (HC).
  • WM microstructure assessed using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD).
  • TBSS and ABA were employed for voxel-wise and region-of-interest analyses, respectively. Correlation with Fugl-Meyer Assessment (FMA) scores.

Main Results:

  • ASSI patients showed reduced FA and increased MD in multiple bilateral WM tracts compared to HC.
  • Significant alterations observed in corticospinal tract, cingulate gyrus, hippocampus, and longitudinal fasciculus.
  • Motor function (FMA scores) correlated with MD and FA in the right cingulate gyrus, hippocampus, and inferior longitudinal fasciculus.

Conclusions:

  • The combined TBSS-ABA approach reliably evaluates WM damage in ASSI.
  • This method precisely identifies and localizes impaired WM regions.
  • Facilitates assessment of motor dysfunction in ASSI patients.