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Efficacy of Multiple Interventions for Moderate to Large Traumatic Tympanic Membrane Perforations: A Systematic
Yueyue Cai1, Rui Lai1, Tingting Zhu2
1Department Of Otorhinolaryngology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Summary
Fibroblast growth factor-2 (FGF-2) combined with gelfoam patching shows the most promise for healing moderate to large traumatic tympanic membrane perforations (TTMP). Ofloxacin otic solution also aids healing, while edge approximation is less effective for TTMP recovery.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Evidence-Based Medicine
Background:
- Moderate to large traumatic tympanic membrane perforations (TTMP) present a significant clinical challenge.
- Optimal therapeutic strategies for TTMP healing remain under investigation, impacting patient recovery and hearing outcomes.
Conclusions:
- Active interventions, particularly FGF-2 based strategies with scaffolds, may outperform watchful waiting for moderate to large TTMP.
- Ofloxacin otic solution may aid in infection control and optimize the middle ear environment.
- Findings are exploratory due to study limitations; large-scale, multicenter RCTs are needed for confirmation.
