Related Experiment Video

Updated: May 26, 2026

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

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Visualization of perivascular spaces in Alzheimer's disease using 5.0 T MRI: A preliminary study

Lijun Dong1,2, Chang Liu1, Xinyi Lv3

  • 1Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Journal of Alzheimer'S Disease : JAD
|May 25, 2026
PubMed

Insights

High-resolution 5.0 Tesla MRI significantly improves visualization of perivascular spaces (PVS) in Alzheimer

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Perivascular spaces (PVS) are implicated in neurodegenerative diseases like Alzheimer's disease (AD).
  • The diagnostic value of 5.0 Tesla (T) magnetic resonance imaging (MRI) for visualizing PVS in AD is not well-established.
  • Understanding PVS in AD is crucial for disease progression and therapeutic strategies.

Purpose of the Study:

  • To evaluate the utility of 5.0 T MRI for assessing PVS in Alzheimer's disease patients.
  • To compare PVS visualization and quantification using 5.0 T MRI versus 3.0 T MRI.
  • To investigate differences in PVS characteristics between AD patients and healthy controls (HCs) using 5.0 T MRI.

Main Methods:

  • 186 participants (62 AD patients, 124 HCs) underwent MRI scans.
  • AD patients received paired 3.0 T and 5.0 T MRI scans; HCs received either 3.0 T or 5.0 T scans.
  • Axial T2-weighted imaging was used for qualitative and quantitative PVS assessment in basal ganglia (BG) and centrum semiovale (CSO).

Main Results:

  • 5.0 T MRI showed significantly higher PVS image quality and severity scores in AD patients compared to 3.0 T MRI.
  • Quantitatively, 5.0 T MRI revealed a greater PVS burden (number, volume, length, curvature) in AD patients' BG and CSO.
  • AD patients exhibited higher PVS severity and burden compared to HCs when assessed with 5.0 T MRI.

Conclusions:

  • 5.0 T high-resolution MRI offers superior image quality for PVS visualization in Alzheimer's disease.
  • This advanced imaging technique provides more detailed morphological information of PVS in AD patients.
  • 5.0 T MRI enhances the detection and characterization of PVS abnormalities associated with Alzheimer's disease.
Keywords:
Alzheimer's diseasecognitive impairmentmagnetic resonance imagingperivascular space

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