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Related Experiment Video

Updated: May 26, 2026

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI

Published on: December 16, 2022

Insights From Spatiality: Accelerating Pharmaceutical Research Using Mass Spectrometry Imaging.

Yuchen Zou¹, Zhiye Yan¹, Weiwei Tang¹

¹State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.

Medicinal Research Reviews

|May 25, 2026

Summary

Mass spectrometry imaging (MSI) visualizes drug distribution and metabolism in tissues. This label-free technology enhances drug development by mapping molecular interactions at cellular resolution.

Keywords:

drug metabolism mass spectrometry imaging pharmacokinetics tissue imaging

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Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section

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Last Updated: May 26, 2026

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI

Published on: December 16, 2022

Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section

Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section

Published on: June 20, 2025

Area of Science:

Pharmacology
Analytical Chemistry
Biotechnology

Background:

Mass spectrometry imaging (MSI) is a label-free technology for visualizing molecular distribution in tissues.
It combines mass spectrometry's molecular specificity with spatial imaging for drug research.
Advances enable cellular-level resolution and analysis of drugs, metabolites, and endogenous molecules.

Purpose of the Study:

To highlight the transformative impact of Mass Spectrometry Imaging (MSI) in pharmaceutical research.
To detail the capabilities and applications of MSI in drug discovery and development.
To showcase recent advancements enhancing MSI's analytical power and resolution.

Main Methods:

Utilizes mass spectrometry coupled with spatial imaging techniques.
Employs label-free analysis for simultaneous mapping of multiple molecules.
Integrates tandem mass spectrometry, ion mobility, and AI-powered data analysis.

Main Results:

Achieved cellular-level spatial resolution for molecular mapping.
Enabled visualization of drug distribution, metabolism, and target engagement.
Provided comprehensive insights into ADMET properties across various organs.

Conclusions:

MSI is an indispensable tool for understanding drug behavior in complex biological systems.
It accelerates drug development by providing detailed spatial and molecular information.
MSI integration with multimodal and single-cell analysis promises further advancements.