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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...

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Related Experiment Video

Updated: May 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Myocardial Infarction With Nonobstructive Coronary Arteries With Coronary Microvascular Dysfunction Associated With

Yuya Ohga1, Tatsuya Nishikawa1, Akeo Hirai1

  • 1Department of Cardiovascular Medicine, Akashi Medical Center, Akashi, Japan, amc1.jp.

Case Reports in Vascular Medicine
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis-associated myocardial infarction with nonobstructive coronary arteries (MINOCA) was diagnosed using invasive coronary function testing and cardiac magnetic resonance (CMR). Treatment led to normalization of symptoms and imaging, demonstrating reversible microvascular ischemic injury.

Keywords:
CMDMINOCAsystemic sclerosis

Related Experiment Videos

Last Updated: May 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Cardiology
  • Rheumatology
  • Vascular Medicine

Background:

  • Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a significant clinical presentation with diverse underlying causes.
  • Coronary microvascular dysfunction (CMD) is a primary driver of MINOCA, quantifiable via invasive coronary physiology indices like IMR and CFR.
  • Systemic sclerosis (SSc) is linked to small-vessel vasculopathy, potentially predisposing patients to CMD.

Purpose of the Study:

  • To report a case of MINOCA attributed to SSc-related CMD.
  • To demonstrate the utility of invasive coronary function testing and cardiac magnetic resonance (CMR) in diagnosing and monitoring SSc-associated MINOCA.
  • To highlight the reversibility of microvascular ischemic injury in SSc-associated MINOCA with appropriate therapy.

Main Methods:

  • A 76-year-old woman with SSc presented with chest pain, ECG changes, and elevated troponin, but no obstructive coronary artery disease.
  • Diagnostic workup included coronary angiography, left ventriculography, CMR, and invasive coronary function testing (acetylcholine provocation, IMR, CFR).
  • Treatment involved calcium-channel blockers and nicorandil, with follow-up assessments including serial CMR.

Main Results:

  • Coronary angiography revealed no obstructive epicardial stenosis, while CMR showed anteroseptal dysfunction with myocardial edema and fibrosis.
  • Invasive testing identified CMD (IMR 30.5; CFR 1.7) after excluding epicardial spasm.
  • At 3-month follow-up, symptoms, ECG, and CMR findings normalized, indicating resolution of ischemic injury. No recurrence observed within 1 year.

Conclusions:

  • SSc-associated MINOCA, driven by CMD, can be diagnosed using comprehensive invasive coronary function testing and CMR.
  • Serial CMR imaging is valuable for assessing the reversibility of microvascular ischemic injury.
  • This case underscores the importance of vasodilator therapy and monitoring in managing SSc-related MINOCA.