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Related Concept Videos

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Updated: May 26, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Development and validation of deprescribing algorithms for kidney failure using consensus development methodology.

Amani Zidan1, Kheloud Awad2, Safeya Habib3

  • 1QU-Health, Qatar University, Doha, Qatar.

Journal of Pharmaceutical Policy and Practice
|May 25, 2026
PubMed
Summary
This summary is machine-generated.

This study developed practical deprescribing algorithms for kidney failure (KF) patients to reduce inappropriate medication use. These validated tools offer clinicians a structured approach to improve medication management and patient safety in KF care.

Keywords:
Deprescribingalgorithmschronic kidney diseaseconsensus methodologyguidelinesinappropriate polypharmacytools

Related Experiment Videos

Last Updated: May 26, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Nephrology
  • Pharmacology
  • Clinical Pharmacy

Background:

  • Patients with kidney failure (KF) face high risks of polypharmacy.
  • Existing deprescribing guidelines have limited applicability in KF settings.
  • Deprescribing interventions are crucial for mitigating polypharmacy in KF.

Purpose of the Study:

  • To adapt existing evidence on deprescribing for kidney failure (KF).
  • To develop practical deprescribing algorithms for clinicians managing KF patients.
  • To support the implementation of deprescribing interventions in KF care.

Main Methods:

  • Reviewed available evidence on deprescribing in KF and local prescribing trends.
  • Convened a panel of experts to develop consensus-based deprescribing algorithms.
  • Validated algorithms with nephrology consultants and clinical pharmacists, followed by pilot testing.

Main Results:

  • Developed one general and 18 drug class-specific deprescribing algorithms for KF.
  • Algorithms provide a structured, stepwise approach to medication assessment and deprescribing.
  • Pilot testing demonstrated feasibility and utility in hemodialysis and low clearance settings.

Conclusions:

  • Developed and validated evidence-based deprescribing algorithms specifically for KF patients.
  • Algorithms offer a practical, structured approach to deprescribing potentially inappropriate medications.
  • These tools aim to support clinicians in optimizing medication regimens for improved patient outcomes.