Correlation between estimated plasma volume status and extracellular volume ratio determined by bioelectrical
Ryo Miyabe1, Akinori Higaki1, Keisho Kurokawa1
1Department of Cardiology, Pulmonology, Hypertension & Nephrology, Ehime University Graduate School of Medicine, Toon, Japan.
Abstract:
This study investigated the correlation between estimated plasma volume status (ePVS), calculated from hematocrit, and the extracellular water-to-total body water (ECW/TBW) ratio measured by bioelectrical impedance analysis in 851 cardiovascular patients. We observed a significant positive correlation between ePVS and ECW/TBW (ρ = 0.491, p < 0.01). Notably, ECW/TBW demonstrated superior performance in identifying elevated B-type natriuretic peptide levels compared to ePVS (AUC: 0.84 [95% CI: 0.81-0.87] vs. 0.75 [95% CI: 0.71-0.80], p < 0.01), suggesting that BIA-derived indices may more accurately reflect cardiac congestion than formula-based plasma volume estimates.
