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Tele-Electrocardiography and Mortality: Clinical Outcomes in Digital Electrocardiography Cohort-Data from Belo
Gabriela Miana de Mattos Paixão1,2, Carla Paula Moreira Soares1, Paulo Gomes Rodrigues1
1Telehealth Center Hospital das Clínicas of the Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Insights
Electrocardiogram (ECG) abnormalities significantly increase mortality risk in Brazil. This large cohort study links ECG data to health records, revealing major abnormalities as strong predictors of death and hospitalization.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Cardiovascular diseases are a leading global and Brazilian cause of death.
- Electrocardiograms (ECGs) are crucial for diagnosing and predicting cardiovascular conditions.
Purpose of the Study:
- To establish the CODE-BH cohort by linking ECG data with hospitalization and mortality records.
- To investigate the association between ECG abnormalities and clinical outcomes in a large Brazilian population.
Main Methods:
- Linked 474,764 ECGs (2006-2018) from 337,021 patients to public health hospitalization and mortality data in Belo Horizonte.
- Utilized probabilistic linkage methods and a standardized questionnaire for clinical data.
- Analyzed mortality rates and associated factors, including ECG findings using Minnesota Code.
Main Results:
- The overall mortality rate was 3.4% over a mean follow-up of 3.3 years.
- Older age, male sex, comorbidities, and major ECG abnormalities were linked to increased mortality.
- Any ECG abnormality, particularly major ones, significantly elevated the risk of mortality and cardiovascular hospitalization.
Conclusions:
- The CODE-BH cohort provides valuable epidemiological data on cardiovascular disease outcomes in Latin America.
- ECG abnormalities are significant predictors of mortality and cardiovascular hospitalization.
- This linkage of ECGs to clinical outcomes offers novel insights for public health research and cardiovascular disease management.
Abstract:
Cardiovascular diseases are the leading cause of mortality in Brazil and around the world. The electrocardiogram (ECG) has a vital diagnostic and prognostic role in cardiovascular diseases. The CODE-BH cohort was established by linking ECG data (2006 to 2018) to hospitalization and mortality data from the public health database of Belo Horizonte, Minas Gerais, Brazil. It comprises 474,764 ECGs from 337,021 patients (mean age 54.42 years; 38.2% male), mostly from primary care centers. Clinical data were collected using a standardized questionnaire. ECG exams, hospitalization, and mortality information system data were linked using probabilistic linkage methods. The mortality rate was 3.4% (n = 11,518) with a mean follow-up of 3.3 years. Mortality was associated with older age, male sex, presence of any comorbidities, and major ECG abnormalities (p < 0.001). The presence of any ECG abnormality by Minnesota Code was associated with a higher risk of mortality (95% CI HR 1.45 (1.36-1.54) for minor abnormalities; HR 2.30 (2.16-2.44) for major abnormalities; p < 0.001), and cardiovascular hospitalization (95% CI HR 1.39 (1.28-1.50) for minor abnormalities; HR 3.12 (2.89-3.37) for major abnormalities; p < 0.001). This cohort brings novel data for epidemiological research. It encompasses a large amount of data from ECGs linked to clinical outcomes from a Latin American population.
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