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Updated: May 26, 2026
06:11
Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
Published on: February 9, 2022
Longitudinal Spirometric Trajectory from Normal Lung Function to PRISm and COPD in a Population-Based Korean Cohort
Sun Young Kang1, Sanghyun Roh2, In Hwan Yeo2
1Institute for Molecular Metabolism Innovation, Soonchunhyang University, Asan, Republic of Korea.
Summary
Preserved ratio impaired spirometry (PRISm) is not a required step for developing chronic obstructive pulmonary disease (COPD). Lung function decline in the general population follows varied paths, not a single linear one.
Area of Science:
- Pulmonology
- Epidemiology
- Respiratory Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) development is characterized by diverse lung function trajectories.
- The role of preserved ratio impaired spirometry (PRISm) in the progression to COPD over time is not well understood.
Purpose of the Study:
- To investigate long-term spirometric trajectories.
- To analyze transitions from normal spirometry to PRISm or COPD within a population-based cohort.
Main Methods:
- Analysis of the Ansan-Ansung cohort data over approximately 12 years and seven examinations.
- Evaluation of longitudinal trajectories for forced expiratory volume in 1 second (FEV1, % predicted) and FEV1/FVC ratio.
- Classification of participants into normal maintenance, PRISm, or COPD trajectory groups using a rule-based approach; COPD defined as FEV1/FVC < 0.70 pre-bronchodilator.
Main Results:
- Lung function decline exhibited heterogeneous trajectories.
- Out of 1,753 participants, 94.6% remained normal, 1.2% developed PRISm, and 4.2% progressed to COPD.
- Most COPD progressions did not involve a preceding sustained PRISm phase; older age and current smoking predicted COPD progression.
Conclusions:
- COPD progression in the general population is heterogeneous.
- PRISm is not an essential precursor to COPD.
- Longitudinal spirometric assessment offers valuable insights beyond single-point classifications.
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