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Published on: March 30, 2019

RNF112 mediates immunosuppression to inhibit the proliferation of cervical cancer by Foxm1

Huiying Pan1, Lei Bao2, Wei Shi1

  • 1Department of Gynecological Oncology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Key Laboratory of Embryo Original Diseases, Shanghai, China.

Translational Cancer Research
|May 25, 2026
PubMed
Abstract

Insights

Ring finger protein 112 (RNF112) acts as a tumor suppressor in cervical cancer by inhibiting proliferation and immune evasion. Low RNF112 levels correlate with poor prognosis, highlighting its clinical significance.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cervical cancer is a major global health concern for women.
  • Molecular mechanisms of cervical cancer progression and immune evasion require further clarification.
  • The role of ring finger protein 112 (RNF112) in cervical cancer is not well understood.

Purpose of the Study:

  • To investigate the expression profile of RNF112 in cervical cancer.
  • To determine the clinical significance of RNF112 in cervical cancer prognosis.
  • To elucidate the molecular mechanisms by which RNF112 influences tumor proliferation and immune responses.

Main Methods:

  • Quantitative PCR and Western blotting to analyze RNF112 expression in patient tissues and cell lines.
  • In vitro and in vivo (xenograft mouse model) experiments to assess RNF112's effect on tumor growth.
  • Co-culture systems and molecular analyses to evaluate RNF112's impact on T lymphocytes, oxidative stress, mitochondrial function, ferroptosis, and Foxm1 ubiquitination.

Main Results:

  • RNF112 expression was significantly downregulated in cervical cancer tissues and cell lines.
  • Low RNF112 expression correlated with poorer patient prognosis.
  • RNF112 suppressed tumor growth, alleviated immunosuppression in the tumor microenvironment, reduced oxidative stress and ferroptosis in T lymphocytes, and promoted Foxm1 ubiquitination and degradation.

Conclusions:

  • RNF112 functions as a tumor suppressor in cervical cancer.
  • RNF112 inhibits cervical cancer proliferation and immune evasion by promoting Foxm1 ubiquitination.
  • RNF112 protects T lymphocytes from oxidative stress, mitochondrial dysfunction, and ferroptosis.
Keywords:
Ring finger protein 112 (RNF112)cervical cancerforkhead box protein M1 (Foxm1)immunosuppression

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