Related Experiment Video
Updated: May 26, 2026

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
Published on: June 13, 2016
A contemporary overview of multiple endocrine neoplasia syndromes: MEN syndromes 1-5 and beyond
Raquel A Maggacis1,2, Alexandra Sorvina3, Lisa J Hayes1,2
1Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Abstract:
Multiple endocrine neoplasia (MEN) syndromes constitute a heterogeneous group of hereditary disorders predisposing to endocrine tumours of varying malignant potential. Recent advances in molecular genetics and tumour biology have significantly reshaped our understanding of underlying pathophysiology, enabling earlier diagnosis, genotype-specific surveillance and the emergence of targeted therapies. This review provides a contemporary overview of key recent advances and consensus guidelines across MEN syndromes, including MEN1, MEN2, MEN4, and MEN5 syndromes, SDHx syndrome, Carney complex, McCune-Albright syndrome, DICER1 syndrome and von Hippel-Lindau syndrome. These insights reflect a rapidly evolving field with genetic diagnosis at the centre of prognostic assessment, targeted surveillance and individualised management.
Related Concept Videos
An Overview of the Endocrine System
The endocrine system collaborates...
Cushing Syndrome II: Pathophysiology
Structures of the Endocrine System
Smooth Endoplasmic Reticulum
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Cushing Syndrome I: Introduction
mTOR Signaling and Cancer Progression
The mTOR pathway or the...