Related Experiment Video
Updated: May 26, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Practical considerations for managing patients being treated with topical roflumilast
Sameh Hanna1,2, Ahmad Chehade3, Christina Han4
1Dermatology on Bloor, Toronto, ON, Canada.
Summary
Topical roflumilast offers effective treatment for skin conditions like psoriasis and dermatitis. Pharmacists must understand its unique safety profile compared to oral formulations to ensure patient safety.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical roflumilast, a phosphodiesterase-4 (PDE4) inhibitor, is approved for plaque psoriasis, atopic dermatitis, and seborrheic dermatitis.
- Oral roflumilast has been used for chronic obstructive pulmonary disease since 2010.
Purpose of the Study:
- To review topical roflumilast safety information in its product monograph.
- To compare pharmacokinetic differences between topical and oral roflumilast formulations.
- To provide guidance for pharmacists on interpreting and applying safety data.
Main Methods:
- Review of product monograph for topical roflumilast.
- Analysis of pharmacokinetic differences between topical and oral administration.
- Evaluation of safety data, drug-drug interactions, and contraindications.
Main Results:
- Topical roflumilast shows significant symptom improvement with good tolerability.
- Product monograph includes oral formulation safety data due to limited long-term topical data.
- No drug-drug interaction studies exist for topical roflumilast.
Conclusions:
- Route of administration significantly impacts drug pharmacokinetics and safety profiles.
- Pharmacists face challenges interpreting and communicating safety information for topical roflumilast.
- Understanding pharmacokinetic differences is crucial for safe and effective patient care.
Related Concept Videos
01:30Asthma-IV: Nursing Management
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...