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Chronotype-based radiotherapy in localised prostate cancer: protocol for a prospective cohort integrating MCTQ and
Rúben Oliveira-Sousa1,2,3,4,5, Íris R Carriço1,2,3,4,6, Catarina Macedo-Silva1,3,4
1Cancer Biology & Epigenetics Group, IPO Porto Research Center (CI-IPO Porto), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.
Abstract:
We present a prospective observational cohort protocol evaluating whether chronotype-based radiotherapy timing reduces treatment-related toxicities in localised prostate cancer. Individual circadian phase is characterised using the Munich ChronoType Questionnaire and salivary dim-light melatonin onset. The primary endpoint is late genitourinary toxicity grade ≥2 at 12 months, with secondary endpoints including gastrointestinal toxicity and patient-reported outcomes. The protocol is conducted at IPO Porto and designed for multi-site adoption.
