Related Experiment Video
Updated: May 26, 2026
10:35
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Material-driven glucose responsiveness in insulin delivery systems: carrier selection and performance
Zhihan Li1, Jingge Jiang1, Ziyu Zhu2
1Department of Pharmacy, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Frontiers in Endocrinology
|May 25, 2026
Summary
Glucose-responsive insulin systems offer improved diabetes management by automatically adjusting insulin release based on blood sugar levels. This review explores advancements in sensing and delivery materials for better glycemic control.
Area of Science:
- Biomedical Engineering
- Materials Science
- Endocrinology
Background:
- Conventional insulin therapy presents challenges in precise dosing and patient adherence, risking hypoglycemia.
- Glucose-responsive insulin delivery systems aim for autonomous, real-time adjustment of insulin release based on blood glucose fluctuations.
Purpose of the Study:
- To systematically review recent advancements in glucose-responsive insulin delivery systems.
- To analyze the evolution of glucose-sensing mechanisms and carrier materials for these intelligent systems.
Main Methods:
- Review of current literature on glucose-sensing strategies (enzymatic, non-enzymatic, transporter-mediated).
- Analysis of advanced carrier materials (metal-organic frameworks, smart polymers, bio-derived materials).
- Evaluation of operational principles, merits, and translational challenges of existing designs.
Main Results:
- Significant progress in glucose-sensing technologies and novel carrier materials.
- Identification of key challenges including biocompatibility, stability, and safety for clinical translation.
Conclusions:
- Glucose-responsive systems hold promise for more physiological glycemic control and improved diabetes management.
- Further research and development are needed to overcome translational hurdles for next-generation therapies.
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