SYTL2 and DENND2B as shared drivers in mouse abdominal aortic aneurysm and lung cancer

Synaptotagmin-like 2 (SYTL2) and DENN domain containing 2B (DENND2B) have been identified as key genes involved in both abdominal aortic aneurysm (AAA) and lung cancer (LC). Utilizing weighted gene co-expression network analysis on transcriptomic data from public databases, this study highlights the significant roles of these genes in disease progression. SYTL2 and DENND2B were found to correlate with survival rates in LC patients, indicating their prognostic importance. Moreover, their diagnostic accuracy for AAA was validated through support vector machine modeling, achieving an area under the curve value of 0.794. Functional analyses revealed these genes' involvement in pathways related to apoptosis, immune cell infiltration, protein-protein interactions, and drug sensitivity, among others. These findings underscore the clinical potential of SYTL2 and DENND2B as biomarkers for disease diagnosis and prognosis evaluation as well as novel molecular targets for therapeutic strategies.