Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 26, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Cystoid Macular Edema in Retinitis Pigmentosa: Pathophysiologic Insight Using Swept-Source OCT and Angiography.

Taariq K Mohammed^1,2, Kyle M Green^1,2, D Brice Critser^1,2

¹Institute for Vision Research, University of Iowa, Iowa City, Iowa.

Ophthalmology Science

|May 25, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

Investigative ophthalmology & visual science·2026

Same author

A Single-Center Analysis of Variables Used to Select a Vitreoretinal Surgery Training Program.

Journal of vitreoretinal diseases·2026

Same author

Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration.

bioRxiv : the preprint server for biology·2026

Same author

Metabolic Analysis of Human Retinal Pigment Epithelium and Choroid Tissue in Aging and Macular Degeneration.

bioRxiv : the preprint server for biology·2026

Same author

Nebular Cortical Cataract in Stickler Syndrome.

Ophthalmology·2026

Same author

Acriflavine delivery via Polyurethane nanocapsules to treat neovascular age-related macular degeneration.

bioRxiv : the preprint server for biology·2026

Same journal

Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Impaired Photoreceptor Function in Age-Related Macular Degeneration.

Ophthalmology science·2026

Same journal

Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

Ophthalmology science·2026

Same journal

Assessing Polypoidal Choroidal Vasculopathy-Related OCT Features in the TENAYA and LUCERNE Trials.

Ophthalmology science·2026

Same journal

Quantitative Analysis of Choroidal Thickness and Blood Flow in Thyroid-Associated Ophthalmopathy Using Ultra-Widefield Swept-Source OCT Angiography.

Ophthalmology science·2026

Same journal

Epiretinal Membrane Is Associated with Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration.

Ophthalmology science·2026

Same journal

Multisource Machine Learning Model for Detecting Referral-Warranted Retinopathy of Prematurity.

Ophthalmology science·2026

See all related articles

This summary is machine-generated.

Cystoid macular edema (CME) in retinitis pigmentosa (RP) is linked to deep capillary plexus (DCP) blood flow loss and preserved outer retinal layers. This suggests impaired fluid clearance mechanisms in the DCP contribute to CME development in RP patients.

Area of Science:

Ophthalmology
Retinal Imaging
Genetics

Background:

Cystoid macular edema (CME) is a frequent complication in retinitis pigmentosa (RP).
The underlying pathophysiology of CME in RP remains poorly understood.
Swept-source (SS) OCT angiography (OCTA) offers novel insights into macular vascular changes.

Purpose of the Study:

To investigate the pathophysiologic mechanisms of CME formation in retinitis pigmentosa (RP).
To correlate structural and vascular abnormalities with CME using SS-OCTA.
To explore genotype-specific prevalence of CME in RP.

Main Methods:

Retrospective cross-sectional study of 70 patients with molecularly confirmed RP.
Multimodal imaging including SS-OCT and SS-OCTA (PLEX Elite 9000).

Keywords:

Cystoid macular edema Inherited retinal disease Optical coherence tomography Optical coherence tomography angiography Retina

More Related Videos

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Related Experiment Videos

Last Updated: May 26, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Semiautomated analysis of images using ImageJ to assess structural and vascular features.

Main Results:

31% of RP patients exhibited CME, with prevalence varying by genotype (RPGR: 10%, USH2A: 36%, RHO: 48%).
Strong spatial overlap (97%) was found between CME and preserved external limiting membrane (ELM).
Significant spatial overlap (83%) existed between CME and deep capillary plexus (DCP) flow loss.

Conclusions:

CME is common in RP, with prevalence influenced by genetic mutations.
Impaired fluid clearance at the DCP level is a likely shared mechanism for CME in RP.
Strong correlation between DCP flow loss and ELM preservation suggests a common pathophysiologic pathway.