Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Bioassay-Guided Fractionation of <i>Citrus</i> Species: Phytochemical Characterization and Nanoformulation of a Polyphenol-Rich Leaf Fraction from <i>Citrus aurantifolia</i> for Skin Anti-Aging Applications.

Nutrients·2026
Same author

Design, Synthesis, and Biological Evaluation of Tetrahydroindazole-Based Sulfonamides as Potential Multi-Target Anti-Inflammatory Agents.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Molecular modeling of highly selective CDK1 Inhibitors based on pyrazolo-pyrimidines using 3D-QSAR, docking, and molecular dynamics simulations.

PloS one·2026
Same author

Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer's Therapy.

PloS one·2026
Same author

Antioxidant and antibacterial potential of bioactive extraction from Cadaba glandulosa leaves.

PloS one·2026
Same author

Identification of antimicrobial compounds in Dipsacus inermis via phytochemical profiling, in vitro assessment, and advanced computational techniques.

PloS one·2026

Related Experiment Video

Updated: May 26, 2026

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
08:33

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors

Published on: January 19, 2015

Human Metapneumovirus Nucleocapsid Inhibitors Discovery for Targeting Viral Replication and Genome Encapsidation: An

Abdullah R Alzahrani1, Talha Jawaid2, Maha M Bakhuraysah3

  • 1Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Al-Abidiyah P. O. Box 13578, Makkah, 21955, Saudi Arabia, uqu.edu.sa.

Journal of Tropical Medicine
|May 25, 2026
PubMed
Summary

New drug candidates show promise for treating human metapneumovirus (HMPV) infections. Computational methods identified compounds that effectively target the HMPV nucleocapsid protein, crucial for viral replication.

Keywords:
computational drug discoveryhuman metapneumovirusmolecular dynamics simulationnucleocapsid

More Related Videos

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

Related Experiment Videos

Last Updated: May 26, 2026

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
08:33

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors

Published on: January 19, 2015

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus
13:48

Reverse Genetics Mediated Recovery of Infectious Murine Norovirus

Published on: June 24, 2012

Area of Science:

  • Virology
  • Computational Chemistry
  • Drug Discovery

Background:

  • Human metapneumovirus (HMPV) is a significant respiratory pathogen.
  • HMPV infections pose severe risks to infants, the elderly, and immunocompromised individuals.
  • No approved antiviral drugs currently exist for HMPV treatment.

Purpose of the Study:

  • To identify novel drug candidates targeting the HMPV nucleocapsid protein.
  • To computationally discover molecules that inhibit viral replication and genome encapsidation.

Main Methods:

  • Applied virtual screening to a compound library.
  • Utilized AutoDock Vina for redocking top compounds.
  • Performed molecular dynamics simulations to assess complex stability.

Main Results:

  • Identified three compounds (24,330,502, 24,292,974, 17,515,455) with high binding affinity and stability.
  • These compounds demonstrated superior performance compared to the reference drug, Gamma-Fagarine.
  • The selected compounds effectively maintained ligand binding within the protein pocket.

Conclusions:

  • Compounds 24,330,502, 24,292,974, and 17,515,455 show potential as HMPV inhibitors.
  • These findings offer a promising avenue for developing new HMPV antiviral therapies.