Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 26, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Altair-dvOPM: an open-access platform for large-field three-dimensional tissue imaging.

Tai Ngo1,2, Muaaz Faiyazuddin1,2, Trung Duc Nguyen1,2

  • 1Lyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Biorxiv : the Preprint Server for Biology
|May 25, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.

Research square·2026
Same author

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.

bioRxiv : the preprint server for biology·2026
Same author

An epithelial morphogenetic program for maximal urine concentration.

Nature communications·2026
Same author

Leptin Receptor <sup>+</sup> cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14.

bioRxiv : the preprint server for biology·2026
Same author

A high-resolution, easy-to-build light-sheet microscope for subcellular imaging.

eLife·2026
Same author

Causal Association Between Atrial Fibrillation and Depression: Evidence From Mendelian Randomization Analyses.

International journal of psychiatry in medicine·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles
This summary is machine-generated.

Altair-dvOPM is an open-access microscope for large-field 3D imaging of cleared and expanded tissues. It achieves micrometer resolution over a wide field of view, enabling detailed visualization of biological structures.

Area of Science:

  • Microscopy and Imaging Technologies
  • Biotechnology
  • Cell Biology

Background:

  • Traditional microscopy methods face limitations in imaging large, cleared, or expanded biological samples with high resolution.
  • There is a need for accessible, versatile imaging systems capable of capturing 3D information across multiple scales.

Purpose of the Study:

  • To introduce Altair-dvOPM, an open-access direct-view oblique plane microscope.
  • To demonstrate its capability for large-field, high-resolution 3D imaging of cleared and expanded tissue sections.

Main Methods:

  • The system utilizes photographic-lens-based detection and externally launched oblique illumination.
  • Precision-registered modular baseplates ensure stability and ease of use.
  • Open-source software facilitates system control and replication.

More Related Videos

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

Related Experiment Videos

Last Updated: May 26, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
09:56

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

Main Results:

  • Achieved micrometer-scale lateral resolution over a ~5.4 mm field of view.
  • Successfully imaged subcellular structures in expanded cells and centimeter-scale tissue sections.
  • Demonstrated the system's versatility across different biological scales.

Conclusions:

  • Altair-dvOPM offers a robust and accessible solution for large-volume 3D tissue imaging.
  • The open-access nature and provided resources encourage further development and adoption.
  • This technology advances capabilities in biological sample visualization and analysis.