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Published on: June 10, 2025
The Factors Associated With Readmission in One Year Among Patients With Chronic Heart Failure: A Retrospective Cohort
Zheng Feng1, Hui Mengyuan1, Cheng Lin2
1Department of Cardiovascular Medicine, Nursing Department, The Third Xiangya Hospital, Central South University, Changsha, CHN.
Insights
Low medication literacy is linked to higher hospital readmission rates in chronic heart failure (CHF) patients. Improving medication understanding can help reduce readmissions for CHF, improving patient outcomes.
Area of Science:
- Cardiology
- Public Health
- Health Literacy
Background:
- Chronic heart failure (CHF) is a significant cause of hospital readmissions.
- Understanding factors influencing readmission is crucial for effective patient management.
- Medication literacy's role in CHF readmission requires further investigation.
Purpose of the Study:
- To identify factors associated with one-year hospital readmission in CHF patients.
- To specifically examine the association between medication literacy and readmission risk.
- To inform interventions for reducing CHF readmissions.
Main Methods:
- Retrospective cohort study of 480 CHF patients from three tertiary hospitals in China.
- Univariate analysis using Chi-squared or Fisher's exact tests.
- Binary logistic regression to determine independent predictors of one-year all-cause readmission.
Main Results:
- 58.1% of CHF patients experienced all-cause readmission within one year.
- Lower medication literacy was an independent risk factor for readmission (OR=0.411).
- Increased readmission risk was associated with longer disease duration (≥10 years), myocardial infarction, higher NYHA class (III/IV), and HFmrEF.
Conclusions:
- Lower medication literacy is a significant, modifiable risk factor for CHF readmission.
- Disease duration, comorbidities like myocardial infarction, and disease severity (NYHA class, HFmrEF) also predict readmission.
- Interventions targeting medication literacy may reduce hospital readmissions in CHF patients.
Abstract:
Objective This study aimed to identify factors associated with readmission in one year among patients with chronic heart failure (CHF), focusing on the association between medication literacy and readmission. Methods This retrospective cohort study included CHF patients diagnosed and treated at three tertiary hospitals in Hunan, China. The Chi-squared test or Fisher's exact test was used for univariate analysis. Binary logistic regression was applied to identify the factors influencing all-cause readmission within one year. Results A total of 480 CHF patients were included. Of note, 58.1% of them (279 CHF patients) were readmitted to the hospital for any cause within one year. The all-cause readmission rates at one month, three months, six months, and one year were 19.7%, 35.8%, 46.9%, and 58.1%, respectively, while the corresponding proportions for HF readmissions were 10.8%, 20.7%, 28.4%, and 37.6%. Medication literacy was an independent risk factor for one year all-cause readmission (odds ratio (OR)=0.411, 95% confidence interval (CI)=0.134-0.743, p=0.013 ), and the following factors were associated with increased risk of all-cause readmissions within one year: disease duration ≥10 years (OR=5.961, 95% CI=1.981-17.939, p=0.001), myocardial infarction (OR=2.818, 95% CI=1.486-5.344, p=0.002), New York Heart Association Functional Classifications (NYHA class) III (OR=2.794, 95% CI=1.442-5.411, p=0.002), NYHA class IV (OR=4.112, 95% CI=1.952-8.664, p<0.001), and heart failure with mid-range ejection fraction (HFmrEF) (OR=2.463, 95% CI=1.241-4.889, p=0.010). Conclusions Our study found that, in addition to longer disease duration, myocardial infarction, higher NYHA class, and HFmrEF, lower medication literacy may be associated with an increased risk of all-cause readmission in patients with CHF. This new finding provides guidance for the future development of prevention and intervention programs aimed at improving the well-being of CHF patients.
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