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Clinical and computed tomography (CT) features of nodular pulmonary histoplasmosis

Fei Li1, Yanli He1, Yanyan Li1

  • 1Department of Radiology, Tangdu Hospital, Fourth Military Medical University (Air Force Medical University), Xi'an, China.

Journal of Thoracic Disease
|May 25, 2026
PubMed
Abstract

Insights

Nodular pulmonary histoplasmosis (NPHP) primarily affects males and is often asymptomatic. High-resolution CT reveals characteristic subpleural solid nodules, aiding diagnosis.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • Pulmonary histoplasmosis is a fungal infection caused by Histoplasma capsulatum, increasingly reported globally.
  • Nodular pulmonary histoplasmosis (NPHP) is a distinct form characterized by granulomatous nodules in lung tissue.
  • NPHP can mimic other lung diseases and often presents with nonspecific or no symptoms.

Purpose of the Study:

  • To analyze high-resolution computed tomography (HRCT) features of NPHP.
  • To correlate HRCT findings with clinical characteristics of NPHP patients.
  • To improve clinician awareness of NPHP in the differential diagnosis of pulmonary nodules.

Main Methods:

  • Retrospective analysis of clinical data, CT imaging, and pathology.
  • Study included 23 patients diagnosed with NPHP between January 2014 and May 2024.

Main Results:

  • NPHP predominantly affects males (69.57%) with an average age of 50.30 years.
  • Most patients were asymptomatic (95.65% had solid nodules).
  • Lesions were often solitary (73.91%), round (65.22%), well-defined (82.61%), and subpleural with pleural adhesion (65.22%).

Conclusions:

  • NPHP is more common in males and frequently asymptomatic.
  • Lesions are typically solitary, well-defined solid nodules, often subpleural with pleural adherence.
  • HRCT findings are key for differentiating NPHP from other pulmonary nodules.
Keywords:
Pulmonary histoplasmosiscomputed tomography (CT)granulomatous diseasepulmonary nodule

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