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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Homocysteine increases phosphorylation and aggregation of α-synuclein.

Soichi Enomoto1, Tadanori Hamano1,2, Rei Asano1

  • 1Department of Neurology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Journal of Clinical Biochemistry and Nutrition
|May 25, 2026
PubMed
Summary

Homocysteine (Hcy) increases alpha-synuclein (α-Syn) phosphorylation and aggregation, promoting Lewy body formation in Parkinson's disease. Folate can reverse these effects, suggesting a therapeutic target.

Keywords:
homocysteineoligomerizationphosphorylationα-synuclein

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