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Published on: April 10, 2018

Functional role of long non-coding RNA MALAT1 and HOTAIR in lung cancer

Hong-Wei Wen1, Ali Afzal2, Guang-Wei Chen3

  • 1Department of Public Health, Zhengzhou Health College, Zhengzhou, Henan, 450000, China.

Non-Coding RNA Research
|May 25, 2026
PubMed

Insights

Long noncoding RNAs (lncRNAs), MALAT1 and HOTAIR, are crucial in lung cancer development and treatment response. This review synthesizes their roles in oncogenesis, chemoresistance, metastasis, and immune modulation for diagnostic potential.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) like MALAT1 and HOTAIR are implicated in tumorigenesis and therapeutic response.
  • Existing literature on their oncogenic pathways is fragmented and lacks context-specific details.
  • Understanding the precise mechanisms and targets of these lncRNAs is essential for advancing cancer research.

Purpose of the Study:

  • To provide an updated synthesis of scattered findings on MALAT1 and HOTAIR in lung cancer.
  • To summarize the oncogenic mechanisms of MALAT1 and HOTAIR.
  • To evaluate their roles in chemoresistance, metastasis, and immune modulation, highlighting diagnostic and translational potential.

Main Methods:

  • Literature review and synthesis of existing studies.
  • Analysis of published data on MALAT1 and HOTAIR functions in lung cancer.
  • Integration of findings on their roles in key oncogenic pathways and clinical relevance.

Main Results:

  • MALAT1 and HOTAIR influence key oncogenic pathways in lung cancer.
  • These lncRNAs are implicated in modulating chemoresistance and metastasis.
  • They also play a role in immune modulation within the tumor microenvironment.

Conclusions:

  • MALAT1 and HOTAIR are significant regulators of lung cancer progression and treatment outcomes.
  • Further research into their mechanisms and targets can enhance diagnostic and therapeutic strategies.
  • Context-dependent roles of these lncRNAs are critical for their translational application in oncology.
Keywords:
ChemoresistanceHOTAIRLong noncoding RNAsLung cancerMALAT1

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