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Updated: May 26, 2026
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Correlation between Staphylococcus aureus colonization and disease severity in atopic dermatitis: a systematic review
Ruyi Jin1,2, Mingyue Wang1,2, Jincheng Ke3
1Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Background:
A positive association between Staphylococcus aureus (S. aureus) colonization and atopic dermatitis (AD) severity has been reported. However, the strength and consistency of this relationship remain unclear.
Methods:
We systematically searched PubMed, Embase, Cochrane Library, and Web of Science up to July 19, 2025. The reported correlation coefficients of studies have been extracted and converted into Fisher's z-scores. The calculated values have been generated using a random-effects model in RevMan software and the final pooled result was converted to a correlation coefficient (r) with 95% confidence intervals. We tested the heterogeneity between the included studies using I². We also provide sensitivity analyzes and subgroup.
Results:
Seven RCTs with 929 participants were included. The pooled analysis showed a moderate positive correlation between S. aureus colonization and AD severity (r = 0.42, 95%CI: 0.31-0.52). The observed heterogeneity was moderate but not significant (I² = 38%, P = 0.14). Sensitivity and subgroup analyzes supported the robustness of the main findings.
Conclusions:
S. aureus colonization is moderately associated with AD severity. However, it should not be interpreted as evidence of a direct causal relationship.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/, identifier CRD420251104116.
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