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Trends in Intensity Modulated Radiation Therapy Utilization for Definitive Treatment of Intact Cervical Cancer,
Sarah S Lee1, Christopher R Weil2, Leslie Boyd1
1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, New York University Langone Health, New York, New York.
Advances in Radiation Oncology
|May 25, 2026
Summary
Intensity Modulated Radiation Therapy (IMRT) use for cervical cancer increased significantly from 2004 to 2019, particularly for advanced stages. This trend highlights the growing adoption of advanced radiation techniques in cancer care.
Area of Science:
- Radiation Oncology
- Medical Physics
- Clinical Oncology
Background:
- Cervical cancer treatment often involves definitive chemoradiation.
- Advancements in radiation therapy techniques aim to improve treatment efficacy and reduce toxicity.
- Intensity Modulated Radiation Therapy (IMRT) offers potential advantages over traditional 3-dimensional conformal radiation therapy (3DCRT).
Purpose of the Study:
- To analyze temporal trends in the utilization of IMRT versus 3DCRT for cervical cancer patients undergoing definitive chemoradiation.
- To identify clinical and demographic factors associated with the adoption of IMRT in this patient population.
Main Methods:
- Retrospective analysis of the National Cancer Database (2004-2019).
- Inclusion criteria: Stage IB2-IVA cervical cancer treated with definitive chemoradiation.
- Statistical methods included Wilcoxon rank-sum tests, chi-square tests, and multivariable logistic regression.
Main Results:
- IMRT use increased from 31% in 2004 to 75% in 2019 (P < .01).
- Stage III disease, lymph node involvement, and treatment in western/southern US were associated with higher IMRT use.
- Black patients and those treated at community hospitals were less likely to receive IMRT.
Conclusions:
- IMRT utilization for cervical cancer has substantially increased over the past 15 years.
- The adoption of IMRT is more prevalent in patients with advanced-stage disease and lymph node involvement.
- Further research into policy, demographic, and practice pattern shifts can illuminate the adoption of advanced radiation technologies.
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