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Published on: August 31, 2016
Longitudinal Health-Related Values Discussions for Patients Undergoing Hematopoietic Stem Cell Transplant: Do Values
Jessica I Goldberg1, Abigail G Cohen1, Jaime L Gilliland1
1Memorial Sloan Kettering Cancer Center.
Research Square
|May 25, 2026
Summary
Hematopoietic stem cell transplant (HSCT) patients with hematologic malignancies (HM) experience changing health-related values (HRV) early in treatment. Ongoing communication is key to aligning care with evolving patient priorities.
Area of Science:
- Hematology
- Palliative Care
- Psychosocial Oncology
Background:
- Hematologic malignancies (HM) pose significant morbidity for patients undergoing Hematopoietic Stem Cell Transplant (HSCT).
- Palliative care addressing health-related values (HRV) is crucial for HSCT patients.
- Previous pilot studies highlighted the benefit of HRV discussions in HSCT.
Purpose of the Study:
- To explore changes in patients' health-related values (HRV) throughout the Hematopoietic Stem Cell Transplant (HSCT) course.
- To identify transitions in value hierarchy among patients with hematologic malignancies (HM).
Main Methods:
- Qualitative content analysis of values discussions with 31 patients undergoing HSCT.
- Repeated assessment of HRV (personhood, sources of strength, future concerns) at key transplant milestones (pre-transplant to 1-year).
Main Results:
- Little change was observed in personhood values.
- Most significant value transitions occurred early post-transplant (Day 10-14 and Day 30).
- Sources of strength and the meaning of living well showed the most variability.
Conclusions:
- Patients with HM undergoing HSCT experience value transitions within the first year post-transplant.
- Patient understanding, prioritization, and reflection on values evolve in response to HM diagnosis and treatment.
- Iterative, person-centered communication is essential for aligning decision-making with patients' dynamic values.
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