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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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Related Experiment Video

Updated: May 26, 2026

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

Invasive group A Streptococcal infections in Franche-Comté, France (2022-2023).

Julie Dias1, Isabelle Patry2, Joséphine Moreau1

  • 1Clinical department of Dermatology and Venereology, University Hospital of Besançon, 3 Boulevard Alexandre Fleming, 25000 Besançon, France.

European Journal of Dermatology : EJD
|May 25, 2026
PubMed
Summary

Invasive group A streptococcal (iGAS) infections surged post-COVID-19 in France, with high rates of severe disease and mortality. Early recognition of streptococcal toxic shock syndrome (STSS) is crucial for better outcomes.

Keywords:
Emm genotypesInvasive group A streptococcal infectionmortalitystreptococcal toxic shock syndrometreatment

Related Experiment Videos

Last Updated: May 26, 2026

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Group A Streptococcus (GAS) circulation increased globally after COVID-19 restrictions eased.
  • Invasive GAS (iGAS) infections represent a significant public health concern.
  • Understanding post-pandemic iGAS trends is vital for clinical management.

Purpose of the Study:

  • To characterize the epidemiology and clinical features of iGAS infections in a French region.
  • To identify risk factors and outcomes associated with iGAS infections post-COVID-19.
  • To evaluate treatment strategies and identify dominant GAS genotypes.

Main Methods:

  • A descriptive retrospective study of confirmed and probable iGAS cases.
  • Data collected from six hospitals in Franche-Comté, France (September 2022 - August 2023).
  • Analysis included clinical presentations, risk factors, treatment, and mortality.

Main Results:

  • 116 iGAS cases analyzed: 99 adults, 17 children.
  • Common presentations: skin/soft tissue infections (31%), osteoarticular (20%), pulmonary (15%).
  • High rates of Streptococcal Toxic Shock Syndrome (STSS) (24%), ICU admission (27%), and mortality (22%).
  • Risk factors: age >65, wounds (adults); viral co-infections, chickenpox (children).
  • GAS emm1 genotype predominated (59%) and was linked to STSS (79%).
  • No beta-lactam resistance observed; 39% received combination therapy.

Conclusions:

  • iGAS infections exhibited diverse clinical presentations and significant severity post-COVID-19.
  • Prompt identification and management of STSS are critical for improving patient prognosis.
  • The emm1 genotype appears to play a key role in severe iGAS cases, including STSS.